Title: Effect of aluminum on learning memory and apoptosis of hippocampus cells in rats
Abstract: Objective To study the effects of aluminum trichloride on learning memory and apoptosis of hippocampus cell.Methods Sprague-Dawley rats were randomly divided into four groups based on their boby weight.Aluminum chloride was added into diet at doses of 0,11.2,55.9and 111.9mg/kg·bw for 90 days successively.Learning and memory abilities were observed by Y-maze.The morphological characters and percent of neuronal apoptosis in hippocampus were identified by teminal deoxynuleotidyl transferase-mediated nick-end labeling(TUNEL) and FACS scan.Aluminum was measured by atomic absorption spectroscopy.Results Correct escaping rate of the rats in the dose group of 111.9mg Al3+/kg·bw was decreased.And escaping latency of rats exposed to doses of 55.9 and 111.9mg/kg·bw was prolonged significantly as compared with the controls.In hippocampus,TUNEL-positive cell could be detected in every treatment group.As the dosage of AlCl3 increased,TUNEL-positive appeared to be more obvious.The rates of apoptosis and aluminum content in hippocampus in every treatment group were significantly increased with a singificant does-response relationship.Conclusion Apoptosis induced by aluminum in rat hippocampus might be one of the important mechanisms of the damage of learning and memory.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 1
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