Title: The corpus callosum in subcortical ischemic vascular dementia: a diffusion tensor imaging study
Abstract: Objective:To investigate whether corpus callosum (CC) abnormalities are present and its characteristic in SIVD and the relationship between the DTI paremeters and cognitive status. Methods:The research was performed in 34 SIVD patients and 26 age-matched nondemented older adults. All patients and controls received DTI examination. For each individual, regional FA(fractional anisotropy), PA(principal anisotropy, FApri) and mean ADC measures were estimated in the splenium and genu of the CC. Results:FA and PA value in the posterior corpus was greater than genu in both control and groups. In SIVD group, FA, PA significantly decreased, and mean ADC significantly increased. Negative correlation was found between MMSE and mean ADC values of genu of corpus callosum (r=-0.361, P=0.036). Conclusions:This finding hints that DTI can find the white matter integrity destruction, demyelination and axon loss of corpus callosum, which may be potential morphological substrates of cognitive dysfunction. DTI appears to be a promising technique for white matter damage differences in SIVD. These results may be helpful for early and accurate prevention and treatment of SIVD, and for preventing or reversing cognitive decline.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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