Title: Plasticity of adult stem cells: transdifferentiation or cell fusion
Abstract:Recent progress in stem cell researches indicates that adult stem cells maintain a high degree ofplasticity for multilineage cell differentiation. Adult stem cells not only can differentiate into the ...Recent progress in stem cell researches indicates that adult stem cells maintain a high degree ofplasticity for multilineage cell differentiation. Adult stem cells not only can differentiate into the cell types of thesame tissues in which they reside, but also may transdifferentiate into a completely different tissue derivative.This transdifferentiation of adult stem cells has become a holy grail of stem cell therapeutics, promising theeventual clinical use of these adult stem cells in regenerating a cornucopia of damaged tissues. However, thereare some other comments doubting its very existence, suggesting that cell fusion may explain some of the observedplasticity of adult stem cells. Here we review plasticity of adult stem cells, transdifferentiation and cell fusion.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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