Title: Pharmacokinetics of Tongxinluo Supermicro Powder in Rats
Abstract: Objective A rapid,sensitive and specific liquid chromatography-tandem mass spectrometric( LC-MS-MS) method was developed and validated for determination of paeoniflorin in rat plasma.The pharmacokinetics of paeoniflorin was evaluated in rats after intragastric administration of TXLSP and provide a firm basis for evaluating the clinical efficacy of TXLSP.Methods The pharmacokinetics of paeoniflorin was evaluated in rats after a single and multiple dosing of 6 g /kg of TXLSP( 24.52 mg /kg,paeoniflorin).The plasma concentration and pharmacokinetic profiles of paeoniflorin was determined.The main pharmacokinetic parameters of paeoniflorin were calculated.Results After single and multiple dosing of TXLSP the main pharmacokinetic parameters were as follows: Cmax 77.8 ng /ml and 189.6 ng /ml; t1 /2( 207.9 ± 138.3) min and( 224.3 ± 120.4) min; AUC0-∞31662 ng.min /ml and 40493 ng.min /ml.Paeoniflorin reached a maximum slowly for single administration and reached a maximum firstly at 28 min and 120 min secondly for multiple dosing.Conclusion It was found that the accumulation achieved with multiple doses of TXLSP.It was indicated that the complex prescription and different dosages can influence the absorption of active ingredient and the clinical efficacy.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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