Title: Reasarch on Quality Standard of Chinese Rhubarb Micro-powder Capsules
Abstract: OBJECTIVE To establish a quality control system for Chinese Rhubarb Micro-powder(CRM) capsules by identification and content determination. METHODS The capsule for CRM was identified by TLC with Chinese rhubarb as indexes. The content of emodin and chrysophanol in the capsule for CRM was determined by improved HPLC. RESULTS The studies on the quality control showed that the characteristic of identification by TLC was distinct,accurate and reproducible. The methodological study showed that a good linear correlation existed in the range of 0. 026 ~ 0. 518μg(r = 1. 0000) of emodin,and 0. 089 ~ 1. 786μg(r = 1. 0000) of chrysophanol respectively. The average recovery of emodin was 101. 23% with RSD of 2. 15%(n = 5) and that of chrysophanol was 98. 25%with RSD of 4. 40%(n = 5). CONCLUSION The methods are accurate and quick in qualitative identification an quantitative assay of this preparation,which can be used for the quality control of Chinese Rhubarb Micro-powder capsules. This improved method of HPLC is high efficient of determination with low cost and light environmental pollution.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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