Title: Advance in the research of new anti-tuberculosis drugs in clinical trials
Abstract: The resurgence of tuberculosis(TB) and the surge of multidrug-resistant of Mycobacterium have reaffirmed tuberculosis as a primary public healthy concern.However,it has been nearly 40 years since the introduction of a new class of effective compounds for the treatment of TB.Therefore,there is an urgent need to develop new antituberculosis drugs.At present,the new drugs that have been in the stage of clinical trial include moxifloxacin,gatifloxacin,rifapentine,rifalazil,TMC207,PA-824,OPC-67683,SQ-109 and LL3858.This article summarized their structures,mechanism,activity and clinical application.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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