Title: The Relevance Between COX-signaling Pathway and Ovarian Cancer Invasion as well as Metastasis
Abstract:Firstly,we sum up some key issues on the occurrence,the development,the invasion and the metastasis research of epithelial tumors,and the way of the expression of COX-2 and zinc finger transcription f...Firstly,we sum up some key issues on the occurrence,the development,the invasion and the metastasis research of epithelial tumors,and the way of the expression of COX-2 and zinc finger transcription factor Snail protein in the development of epithelial tumors and its regulatory aspects.Then the paper preliminarily explores the signal significance of cyclooxygenase-signaling pathway(COX-PGEs-dependent pathway) in epithelial ovarian cancer invasion and metastasis:the high expression of COX-2 in the occurrence and development of ovarian cancer can lead to increased levels of prostaglandin E,consequently increasing the zinc-finger transcription factor Snail protein expression,while the binding of Snail protein and E-cadherin promoter effect on the E-Box element inhibits E-cadherin transcription,because E-cadherin reduction as a cell adhesion molecule may promote tumor cell invasion and metastasis potential.Lastly the paper reviews the COX-signal channels and invasive behavior of malignant tumor cells,the mechanism of influence,and the zinc-finger transcription factor Snail as the invasive and metastatic potential of ovarian cancer marker protein.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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