Title: The clinical effects of selective hypothermia and decompressive craniectomy on severe traumatic brain injury
Abstract: Objective To investigate the clinical effects of selective hypothermia and decompressive craniectomy(DC) on severe traumatic brain injury(sTBI). Methods Methods 37 patients with sTBI were divided into 2 groups: the therapeutic group(selective hypothermia with DC,n=16) and the normothermia control group(n=21).Selective hypothermia had been achieved by head and neck cooling for 4 days with natural warming.The intracranial pressure,good neurological outcome(Glasgow Outcome Scale score of 4 to 5) rates in 6 months after injury and main complications were detected. Results At 24,48 and 72 hr after injury,the mean intracranial pressure(ICP) value of the patients in the therapeutic group was lower than that of in the control group(19.5±2.6,20.3±1.7 and 17.3±1.9 mmHg,versus 23.1±2.1,20.1±1.5,and 20.7±1.4 mmHg,respectively,P 0.05).Good neurological outcome(Glasgow Outcome Scale score of 4 to 5) rates in 6 months after injury were 81.3% in the therapeutic group and 47.6% in the control group respectively(P 0.05).Whereas,there were more cases complicated with subdural effusion in the therapeutic group than those in the control group(43.8% and 9.5%,respectively,P 0.05). Conclusion Selective hypothermia and DC in sTBI is a safe and effective method,which can reduce ICP and improve prognosis.However,it increases the incidence of subdural effusion in sTBI.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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