Title: Experimental Study of Rabbit Femoral Head Avascular Necrosis Model by Liquid Nitrogen Freezing
Abstract: Objective: To establish the animal model for the study of anemic necrosis of the femoral head.Methods: The animal model of bone defect of bilateral femoral heads was established in 40 healthy Rabbits.The femoral heads from bone defect were frozen by liquid nitrogen.Four rabbits was brought to the death every 2,4,6,8,weeks.X-ray and gross-model observation were studied after the model had made for 2,4,6,8 weeks.Results:(1)Gross-model observation: Most of the femoral heads was normal,at second week.Some cartage was stripped from the femoral heads at 4 and 6 weeks after treatment.Some heads was deformed at 8 weeks.(2)X-ray: the femoral head was normal at 2 weeks after operation.Bone density was increased at 4 and 6 weeks after operation found 6 weeks after operation.Cystis degeneration and collapse can be seen in some specimens at 8 weeks after operation.Conclusion: The animal model of bone defect and necrosis of the femoral head in Rabbits could be suited to mimic the clinical situation to study the treatment of anemic necrosis of the femoral head.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot