Title: CLINICAL APPLICATION OF SERUM AFP,CEA AND CA125 IN PATIENTS WITH OVARIAN TUMORS
Abstract: Objective:To evaluate the clinical use of AFP,CEA,CA125 in diagnosis and monitoring the course of patients with ovarian tumors.Methods:Serum levels of AFP,CEA,CA125 were measured by chemiluminescence immunoassay (CLIA) in 47 healthy women,62 patients with benign ovarian tumors,12 patients with ovarian chocolate cyst,and 41 patients with ovarian carcinoma.Results:The serum AFP,CEA and CA125 positive rate were 9.7%,26.8% and 82.5% in ovarian carcinoma.The combination of AFP,CEA and CA125 assays was more sensitive,the total positive rate was 95.1%.AFP,CEA and CA125 levels were within normal range among most healthy women and patients with benign tumors. Sometimes CA125 level was high in patients with ovarian chocolate cyst.The serum levels and positive rate of CA125 in patients with Ⅲ,Ⅳ FIGO stages varian carcinoma were more higher than Ⅰ,Ⅱ stages. Conclusion:Combined measurement of AFP,CEA with CA125 was useful for the differential diagnosis and achieving higher positivity in patients with ovarian carcinoma.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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