Title: Clinical study on adenosine cyclophosphate combined with simvastatin in treatment of chronic heart failure
Abstract: Objective To investigate the clinical effect of adenosine cyclophosphate combined with simvastatin in treatment of chronic heart failure. Methods Patients(120 cases) with chronic heart failure of Department of Cardiovascular Medicine in Tianjin Beichen Hospital from September 2012 to September 2012 were randomly divided into control and treatment groups. Each group had 60 cases. Patients in control group were po administered with Simvastatin Tablets on the basis of conventional therapy, 10 mg/time, three times daily. Patients in treatment group were iv Meglumine Adenosine Cyclophosphate Injections 120 mg on the basis of control group, once daily. The patients in two groups were treated for 2 weeks. The efficacy, cardiac function indicators left ventricular ejection fraction(LVEF), ratio of peak systolic velocity(E/A), shortening fraction(FS), serum factors brain natriuretic peptide(BNP), high-sensitivity C-reactive protein(hs-CRP), blood uric acid(UA), interleukin 6(IL-6), tumor necrosis factor-a(TNF-α), blood lipid levels triacylglycerol(TG), total cholesterol(TC), low density lipoprotein-cholesterol(LDL-C), and high density lipoprotein-cholesterol(HDL-C) were compared. Results The clinical efficacy in treatment group(93.33%) was higher than that in control group(80.00%) with significant difference(P 0.05). After treatment, LVEF, E/A, and FS were significantly higher than those of same group before treatment. And LVEF, E/A, and FS in treatment group were higher than those in control group, and the difference was statistically significant(P 0.05). BNP, hs-CRP, UA, IL-6, and TNF-α were significantly higher than those of same group before treatment. And BNP, hs-CRP, UA, IL-6, and TNF-α in treatment group after treatment were lower than those in control group with significant difference(P 0.05). TC, TG, and LDL-C were significantly lower than those of same group before treatment, while HDL-C was higher than that of same group before treatment(P 0.05). There was no significant difference in TC, TG, LDL-C, and HDL-C between two groups after treatment. Conclusion Adenosine cyclophosphate combined with simvastatin has good efficacy in treatment of chronic heart failure, and can greatly improve the cardiac function and serum factors of patients.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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