Title: Protective effect of adenosine preconditioning on the lungs during open heart surgery under cardiopulmonary bypass
Abstract: Objective:To observe the protective effect of adenosine preconditioning on the lungs during open heart surgery under cardiopulmonary bypass(CPB).Methods:Fourty-eight patients undergoing cardiac valve replacement were randomized into two groups with 24 cases each.Group A was infused adenosine 1.5 mg/kg before CPB,while group B received normal saline as the control.Blood samples were taken from left and right atrium for the measurements of PMN and PLT before CPB and at 10 min after the heart resuscitation.Serum concentrations of tumor necrosis factor-α(TNF-α),interleukin(IL)-8 and IL-10 were detected before CPB,and at 2,6 and 16 h after the aorta was opened.Pulmonary compliance and airway pressure were recorded.Oxygennation index(OI) was calculated.Results:Pulmonary compliance,airway pressure and OI of group A were significantly superior to those of group B(P0.05).The increases of PMN and Plt of right and left atrium after rebeating of the heart were greater in group A than those in group B[(0.46±0.52) 109/L vs.(2.41±0.89) 109/L and(9.07±14.22)109/L vs.(22.67±14.27)109/L] (P0.05).After the aorta was opened,IL-10 expresion was higher,but TNF-α and IL-8 expresions were lower,in group A than those in group B(P0.05).Conclusion:Exogenous adenosine has a protective effect on the CPB-induced lung injury in the patients undergoing cardiac valve replacement.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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