Title: The expression of Smad4 protein in gastric carcinoma and its significance
Abstract: Objective To investigate the expression of Smad4 in gastric carcinoma and its significance.Methods Immunohistochemistry method of S-P was used to examine Smad4 expression in 64 primary gastric cancerous tissues and normal tissues.Results Immunohistochemical assay demonstrated that Smad4 mainly existed in the cytoplasm of normal gastric tissue and cell nucleus of some gastric cancerous tissue.Positive Smad4 expression in well,moderate and poorly differentiated adenocarcinoma tissues was 65.14%、58.12% and 32.28%.Conclusion With decreasing of differentiation of gastric carcinoma,the ratio of positive Smad4 expression in gastric cancerous tissue declines. It was suggested that loss of Smad4 destroyed the signal pathway of the transforming growth factor β,which weakened the function of cell growth in gastric carcinoma.Therefore, the reduced Smad4 expression facilitated the development and metastasis of gastric carcinoma.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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