Title: The roles of PSA,PSAD,f/tPSA in early diagnosis of prostate cancer
Abstract: Objective To study the early diagnostic value of prostate-specific antigen(PSA),density of PSA(PSAD),free/total prostate-specific antigen ratio(f/tPSA) for prostate cancer.Methods prostate biopsy was performed in 640 subjects;among them,36 subjects had PSA4.0 ng/ml and positive findings for digital rectal examination and transrectal ultrasound,which were suspicious of cancer.The patients with bisectional prostate hypertrophy(BHP,415 cases) and prostate cancer(PCa,225 cases) were diagnosed by pathobiology,and whose levels of PSA,and fPSA were examined in serums by ELISA.The volume of prostate were examined by transrectal ultrasound,The associations of PSA,PSAD and f/tPSA with the prostate biopsy results were analyzed.Results PSA and PSAD levels in serum of patients with PCa was higher than BPH,f/tPSA was lower,they have statistics difference between PCa and BPH(P0.001),but in the subjects with PSA4.0ng/ml PSA had no significant difference(P0.05) between patients with prostate cancer and patients with BPH.Conclusion The clinical application of f /t PSA ratio and PSAD can improve diagnosis of prostate cancer.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot