Title: The protective effects of edaravone to cerebral ischemia reperfusion injury during aortic arch replacement surgery
Abstract: Objective:To investigate the protective effects of edaravone to cerebral ischemia reperfusion injury for patients undergoing deep hypothermic circulatory arrest(DHCA) during great artery surgery.Methods:A total of 60 patients undergoing total aortic arch replacement combined with elephant trunk implantation from to were recruited.They were randomly divided into two groups: edaravone group(Group Y,n=30) received edaravone 0.5 mg/kg in normal solution,and control group(Group C,n=30) received placebo.Two groups were inducted and maintained by the same anesthetic medications.During the operation,the anesthesia medications were dosed in the same way.Blood samples were collected from intrajugular vein for determination of serum levels of super oxide dismutase(SOD),malondialdehyde(MDA),neuron-specific cenolase(NSE) and total antioxidant capacity(TAOC) at following 6 time-points,before the begining of surgery(T1),after cessation of DHCA for 5min after(T2),1h(T3),2h(T4),6h(T5) and 24h(T6).Results: There were no significant differences in serum levels of SOD、MDA、NSE and TAOC between the two groups at point of T1 The serum levels of NSE、MDA and TAOC were significantly increased at points after cessation of DHCA(T2-5) compared to the value at point of T1.SOD activity and TAOC at points of cessation of DHCA(T2-5) were significantly higher in the experimental group than those in the control group(P0.05 or 0.01).The serum levels of NSE and MDA after cessation of DHCA(T2-5) were significantly lower in the experiment group than those in the control group(P0.05,P 0.01).Conclusion: Edaravone can attenuate cerebral injury during aortic surgery with DHCA.Edaravone used in aortic surgery with DHCA can eliminate OFR effectively,protect the activity of SOD,increase the activity of TAOC and decrease production of MDA,which can reduce the cerebral ischemia-reperfusion injury and attenuate cerebral injury.Therefore,edaravone play a cerebral protective role during even after the operation.As the result,the prognosis of patients can be ameliorated.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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