Title: Significance of Immunophenotype in Differential Diagnosis of Chronic B Lymphocyte Proliferation Disease
Abstract:Based on the immunophenotype,chronic B lymphocyte proliferation disease can be categorized into different isoforms. Immunophenotype plays an important role in diagnosis and differential diagnosis of a...Based on the immunophenotype,chronic B lymphocyte proliferation disease can be categorized into different isoforms. Immunophenotype plays an important role in diagnosis and differential diagnosis of all subtypes. The typical( chronic) immunophenotype of B-CLL are CD5 +,CD23 +,FMC-7+. HCL specifically expresses CD22,CD25,CD103and CD11c. FL mainly expresses CD20,CD10,CD22and CD79a,but it doesn't express CD5. MCL over-expresses CD5 +,FMC7+,Bcl-2+and cyclinD1+. Typical WM doesn't express CD5 and CD23,but the variant does. The typical immunophenotype of MZL are CD5-,CD10-,CD23-and cyclinD1-. As for variants of BclPD,pathology,genetics,molecular biology should be correlated for diagnosis, so as to guide the clinical treatment and prognosis.Read More
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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