Title: Protective effects of ulinastatin on hepatic ischemia reperfusion injury in patients during orthotopic liver transplantation
Abstract: Objective To evaluate the levels of IL-8 and TNF-α in patients during orthotopic liver transplantation(OLT),for investigating the protective effects of ulinastatin on hepatic ischemia reperfusion injury.Methods Sixty patients with end-stage liver diseases undergoing OLT were randomly divided into three groups of 20 each : ulinastatin I(U_1),ulinastatin Ⅱ(U_2) and control group(C).After skin incision,the three groups were given intravenously ulinastatin 100 000 U/h,ulinastatin 200 000 U/h, and isovolumetric normal saline,respectively,with a micropump.Blood samples were taken before skin incision,40 min in anhepatic phase,30 min、90 min、180 min,and 24 h after reperfusion of graft for determination of plasma IL-8 and TNF-α.Results In group C,compared with the baseline values,concentrations of IL-8 in plasma increased from the time of skin incision,markedly at 30 min and reached the peak at 180 min after reperfusion of graft,and then dropped down.However,the concentrations of TNF-α in plasma increased from 30 min after reperfusion of graft and dropped down from 24 h after operation.In group U_1,concentrations of IL-8 in plasma increased from 180 min after reperfusion of graft and dropped down at 24 h after operation,but concentrations of TNF-α increased without significant difference,compared with the baseline values.In group U_2,concentrations of IL-8 increased not significantly during operation,and concentrations of TNF-α were undetectable by this method.Conclusion Ulinastatin inhibits the release of IL-8 and TNF-α to different degree and alleviates hepatic ischemia reperfusion injury during OLT.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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