Title: Studies of Effect and Mechanism of Turong Bushen Recipe on Stimulating Ovulation of Polycystic Ovary Syndrome Rats
Abstract: Objective:To inves tigate the effect and mechanism of Turong Bushen Recipe(TBR) on stimulating ovulation of rats with polycystic ovary syndrome(PCOS). Methods:Gastric adminis tration of Letrozole for 21 days was used to es tablish PCOS model,and then the modeled rats were randomized into 5 groups,model group,positive control group(clomiphene at 5mg/kg),and high-,middle-,and low- dose TBR groups(in the dos age of 68,34g,17g/kg,res pectively). After treatment,rat body weight,ovaries index,ovarian his topathology,serums exual hormones levels,conception rate and off- spring birth rate were observed for evaluating therapeutic effect. Results: The body weight, ovarian weight and ovaries index were reduced,serum levels of luteinizing hormone and testosterone were decreased,and serum estrogen,progesterone and follicle stimulating hormone were increased in three TBR groups and positive control group(P0.05,P0.01 compared with the model group). High- and middle- TBR groups and pos itive control group had an effect on promoting the follicular maturation,increas ing s inus oid ovarian follicle number and corpus luteum,and enhancing the conception rate and off- s pring birth rate(P0.05,P0.01 compared with the model group). Conclusion:Turong Bushen Recipe(TBR) has certain effect on promoting ovulation in PCOS rats,and regulation of the sexual hormone levels is one of its mechanisms.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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