Title: Sequential therapy of ofloxacin on bacterial infections
Abstract: AIM:To evaluate the efficacy,safety and possibility of the sequential therapy with intravenou and oral form of ofloxacin in patients with bacterial infections. METHODS:Forty-five patients of respiratory and urinary infections(M 21,F 24,age 49±s 18 a) were initially treated with ofloxacin 200 mg,iv,q 12h,the duration for RTI (respiratory tract infections) was 6.0±2.0 d and UTI(urinary tract infections) 4.0±1.0d,then followed by oral administration of ofloxacin 200~300 mg, bid, the durations for RTI and UTI were 7.0±2.0d and 6.0±2.0 d respectively. RESULTS:The total clinical effective and bacterial eradication rates were 84% and 86% respectively. Adverse reactions occurred in 13% of the patients. Result of MIC showed that the antibacterial activities of ofloxacin for Enterobacteriaceae and other Gram-negative organism were higher than those of ampicillin,cefazolin,and gentamicin,similar to those of ciprofloxacin,piperacillin and cefoperazon. CONCLUSION:Sequential therapy of ofloxacin intravenously and orally is effective and safe in patients with bacterial infections.
Publication Year: 1996
Publication Date: 1996-01-01
Language: en
Type: article
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