Title: Reverse effect of left ventricular hypertrophy and changes of plasma endothelin by losartan in elderly patients with essential hypertension
Abstract: AIM: To study the reverse effect of left ventricular hypertrophy(LVH) and changes of plasma endothelin(ET) in elderly patients with essential hypertension(EH) by losartan.METHODS:The changes of plasma ET and blood pressure in 26 hypertensive patients with LVH(LVH group) and 32 elderly essential hypertensive patients without LVH(EH group) before and after losartan 50 mg per day treatment for 16 wk were observed compared with 20 normotensive.The left ventricular posterior wall thickness (LVPWT),the interventricular septal thickness(IVST),left ventricular end diastolic dimension(LVDd),left ventricular mass(LVM) and left ventricular mass index(LVMI) before and after losartan treatment in LVH group,were measured by ediocardiography.RESULTS:The mean arterial pressure(MAP) and plasma ET in EH and LVH group were significantly decreased after losartan treatment,a positive correlation between the plasma ET in LVH group and LVM,LVMI was found.LVDd,IVST,LVPWT,LVM and LVMI in LVH group were also significantly reduced after losartan treatment.CONCLUSION:Therapy with losartan in elderly EH patients can not only effectively decrease blood pressure and plasma ET but also beneficialy reverse LVH.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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