Title: Effects of sitagliptin combined insulin on 46 patients with type 2 diabetes mellitus
Abstract: AIM To investigate the efficacy of sitagliptin on type 2 diabetes mellitus with unsatisfied blood glucose level after insulin treatment.METHODS In this randomized,single -blind,placebo controlled study,98 patients with type 2 diabetes without reaching glycemic targets were randomized into two groups.Fifty patients in the sitagliptin group received sitagliptin 100 mg·d~(-1),while the other 48 patients in the placebo group received placebo individually,with a course of 24 wk for each.The levels of fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PBG),glycosylated hemoglobin A_(1c)(HbA_(1c)),24 h area under the curve (AUC) of glucose,the blood glucose coefficient of variation(CV),fasting and 2 h postprandial serum C- peptide(CP) and glucagon,body weight and the times of hypoglycemia were observed before and after the treatments.RESULTS There were no significantly difference in baseline characteristics between two groups(P 0.05),while 46 and 45 patients finished study in the sitagliptin and placebo group respectively.After 24 wk treatment,no obvious changes occurred but 24 h AUC of glucose increased(P 0.05) in the placebo group. The levels of FBG,2 h PBG,HbA_(1c),AUC of glucose,CV of glucose,fasting and 2 h postprandial serum glucagon decreased(1.5±0.9) mmol·L~(-1),(2.9±3.3) mmol·L~(-1),(0.8±1.6)%,(2 782±901) mmol·L~(-1), min,2.1±1.2,(29.1±19.2) ng·L~(-1) and(42.4±25.4) ng·L~(-1) in the sitaglipin group(P 0.05) and were lower than those in the placebo group(P 0.05).The fasting and 2 h postprandial serum CP increased(0.15±0.21)μg·L~(-1) and(0.79±0.68)μg·L~(-1),and were higher than those in the placebo group(P 0.05).The total times of hypoglycaemia per month decreased in the sitagliptin group and was lower than that in the placebo group.No serious adverse reaction occurred in both groups.CONCLUSION Sitagliptin may improve the level and fluctuation of blood glucose in type 2 diabetic patients with insulin treatment.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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