Title: Expression and significance of survivin and p53 in esophageal squamous carcinoma
Abstract: Objective To study the expression of survivin and p53 and their significance in esophageal squamous carcinoma(ESC).Methods The expression of survivin and p53 was examined immunohistochemically by SP and PowerVision~(TM)-9000(PV-9000) methods in 60 cases of ESC,15 cases of esophageal benign tumor and 10 specimens of adjacent normal esophageal mucosa.Results The positive expression rate of survivin and p53 in ESC were 71.67% and 65.00%,respectively.There was significant difference between ESC and esophaseal benign tumor(13.33%,0),adjacent normal mucosa(0,0,P0.001).The expression intensity of survivin and p53 correlated with histopathological grade,clinical stage and lymph node metastasis(P0.05).There was no correlation between the expression intensity of survivin,p53 and the location,the length of ESC(P0.05).Kendall positive correlation was found between the expressive intensity of survivin and p53(P0.01).Conclusion The results suggest that survivin and p53 may play certain roles in the oncogenesis and progression of ESC,and may have synergetic action in the development of ESC.Cmbined detection of the expression of survivin and p53 may be useful for evaluating malignancy and prognosis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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