Title: Clinical observation on 60 cases of Methimazole treatment of hyperthyroidism-induced leukopenia
Abstract:Objective To investigate causes and remedies for Methimazole treatment of hyperthyroidism-induced leukopenia.Methods Clinical data of 60 patients with the application of Methimazole treatment of hyper...Objective To investigate causes and remedies for Methimazole treatment of hyperthyroidism-induced leukopenia.Methods Clinical data of 60 patients with the application of Methimazole treatment of hyperthyroidism-induced leukopenia were retrospectively summarized.Results Leukopenia occurred in sixty patients within the first and sixth week of treatment.All these symptoms(60/60) occurred during the intake of Methimazole(15~30 mg/d).Due to the lack of granulocyte,6 patients switched to 131I.25 patients had normal white blood cell count and neutrophil count 1 week after elevated white blood cell treatment.28 patients gradually returned to the normal after 2 weeks of treatment.One case returned to the normal in 4 weeks.Conclusion Drug toxicity and genetic susceptibility may be the main cause for Methimazole-induced leucopenia.Once leucopenia occurs,it should be addressed promptly.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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