Title: Effects of Continuous Perfusion of Pulmonary Arteries with Low Blood Flow during Total Cardiopulmonary Bypass on Lung Function
Abstract: To study the effect of continuous perfusion of pulmonary arteries with low blood flow during total cardiopulmonary bypass on the lung function.【Methods】 Ten mixed-breed dogs(18-22 kg) were randomly divided into the control group(n = 5) and pulmonary perfusion group(n = 5).All dogs underwent total cardiopulmonary bypass for two hours.The continuous pulmonary perfusion with 30 mL/(kg·min) flow was used in pulmonary perfusion group.The lung dynamic compliances and oxygen index were detected before bypass,at the end of bypass,1 h after bypass,and 2 h after bypass.The concentrations of monodialdehyde(MDA),activity of superoxide dismutase(SOD),intercellular adhesion molecular-1(ICAM-1) and P-selectin in blood sample from pulmonary vein at respective time were assayed.【Results】 The lung dynamic compliances and oxygen index of pulmonary perfusion group were better than those of control group after bypass(P 0.05).The concentration of MDA of pulmonary perfusion group was lower than those of control group,and SOD activity of pulmonary perfusion group was higher than those of control group(P 0.05).The concentrations of ICAM-1 and P-selectin of pulmonary perfusion group were lower than those of control group after bypass(P 0.05).【Conclusion】 Continuous perfusion of pulmonary arteries with low blood flow can prevent lung injury related to the ischemia-reperfusion injury and activation of adhesion molecular during total cardiopulmonary bypass.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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