Title: Correlation between alteration of tumor suppressor gene p53, p16 and biological behavior of gastric cancer
Abstract: IM To study the correlation between abnormality of tumor suppressor gene p53, p16 and biological behavior of gastric cancer. METHODS P53 and P16 protein expressions of 58 cases of primary gastric cancer (38 males, 20 females, aged from 37 to 76 years) were detected by the immunohistochemical methods (ABC). All samples were freshly obtained and immediately fixed with 850g/L ethanol, embedded with paraffin and setioned serially. RESULTS The positive expression rate of P53 and P16 protein was 517% (30/58) and 483%(28/58), respectively. Positive expression rates of P53 protein in the poorly differentiated gastric cancer (704%), advanced gastric cancer (569%) and lymphnode involved cancer (741%) were higher than those of the highly differentiated, early and lymph node uninvolved ones(273%,143% and 323%) (P005), and high expression of p53 protein was more frequently observed in the diffuse type (in comparison with the intestinal type) and serosal invasion ones (in comparison with mucosa located ones) (P005). Expression of P16 protein was not relevant to most of biological behavior of gastric cancer, but there was a significant difference in p16 expression between lymph node involved ones (333%) and lymph node uninvolved ones (613%) (P005). Relationship analysis indicated that most of p53 positive tissues were accompanied by P16 protein expression (P005). CONCLUSION P53 protein abnormality exerts a extensive effect on biological behavior of gastric cancer. Deletion of P16 protein is mainly involved in lymph node metastasis.
Publication Year: 1997
Publication Date: 1997-01-01
Language: en
Type: article
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Cited By Count: 3
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