Title: Expression of VEGF and MMP-7 at Different Levels of Glioma and its Clinical Significance
Abstract: Objective To investigate the expression of VEGF and MMP-7 at different levels of glioma and its clinical significance.Methods The expression of VEGF and MMP-7 in 78 cases of glioma and 10 cases of normal brain tissue was detected by using the immunohistochemistry PV-9000 two step method.Results The expression of VEGF and MMP-7 was negative in the normal brain tissue,and higher expression of VEGF and MMP-7 could be observed with the increasing level of glioma.There was a significant difference in the expression of VEGF and MMP-7 between glioma and normal brain tissue.Conclusion The accumulation of VEGF in cytoplasm can promote the MMP-7 expression,and VEGF and MMP-7 might be associated with the occurrence,development and malignance of glioma,showing the malignant degree,patholgical level and prognosis of glioma.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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