Title: Expressions and Significances of c-erb B-2,bcl-2 and nm23 Protein in the Colon Carcinoma Tissues
Abstract: Objective:to investigate the expressions and significances of c-erb B-2,bcl-2 and nm23 protein in the colon carcinoma tissues.Methods:the expressions of c-erb B-2,bcl-2 and nm23 protein were determined by immunohistochemical staining in the 45 patients with colon carcinoma.Results:the expressions of bcl-2 and nm23 protein were not correlated with tumor volume(P0.05),but c-erb B-2 protein had the significant correlation with tumor volume(P 0.01).The expressions of c-erb B-2,bcl-2 protein were correlated with tumor differentiation grades,but expressions of nm23 protein was not.C-erb B-2,bcl-2 and nm23 protein expressions were related with depth of invasion,lymph node metastasis and distant metastasis.Conclusion The abnormal expressions of c-erb B-2,bcl-2 and nm23 protein have the important significances in the development and metastasis of colon carcinoma.The combined examination of c-erb B-2,bcl-2 and nm23 protein may be useful for the predicting of metastasis and the prognosis of patients with colon carcinoma.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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