Title: Metabonomic Study on the Toxicity of Chinese Medicine(II): Hepato-nephrotoxicity of Pyrrolizidine Alkaloids
Abstract:OBJECTIVE To study the hepato-nephrotoxicity of pyrrolizidine alkaloids isolated from Herba Senecionis Scandentis via analyzing changes of endogenous metabolites in rat urines after administration of ...OBJECTIVE To study the hepato-nephrotoxicity of pyrrolizidine alkaloids isolated from Herba Senecionis Scandentis via analyzing changes of endogenous metabolites in rat urines after administration of the alkaloids,and provide a simple and reliable method for toxicity evaluation of traditional Chinese medicine(TCM).METHODS The hepato-nephrotoxicity of the alkaloids was explored through analyzing urines collected from rats in both the control and pyrrolizidine alkaloids orally administrated groups in 7 days by bio-nuclear magnetic resonance(bio-NMR),and evaluating pyrrolizidine alkaloids' influences on endogenous metabolites in urine by pattern recognition technique and principal component analysis(PCA).RESULTS Compared with the control group,the continuous increase of taurine,trimethylamine-N-oxide(TMAO) and dimethylglycine(DMG) in urines of pyrrolizidine alkaloids orally administrated group proved that alkaloids had caused damages to the liver and kidney,which indicated the hepato-nephrotoxicity of pyrrolizidine alkaloids.CONCLUSION The hepato-nephrotoxicity of Herba Senecionis Scandentis could be explained from the metabonomics point of view,suggesting that the metabonomic method might provide a new approach for the evaluation of the toxicity of TCM.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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