Title: Effects of short-term running exercise on spatial learning capacity of middle-aged and aged rats
Abstract: AIM: To investigate the effects of short-term running exercise on the spatial learning capacity of middle-aged and aged rats.METHODS: Fourteen months and twenty-four months aged male and female SD rats were randomly assigned to running group and control group.The rats in running group took treadmill exercise for 4 months.The rats in control group were housed under standard condition for 4 months without running.The spatial learning capacity of animals in both running group and in control group was then assessed using Morris Water Maze.RESULTS: The running exercise significantly improved the spatial learning capacity of the 18-month female rats,but the difference in the spatial learning capacity of the 18-month male rats between running group and control group was not statistically significant.The spatial learning capacity of the 28-month male and female rats between running group and control group was not significantly different.CONCLUSION: Short-term running exercise remarkably improves the spatial learning capacity of middle-aged female rats.This result provides an important theoretical basis for the application of similar strategy to delay the progress of brain function decline with aging.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 1
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