Title: Effect of carvedilol on plasma BNP and left ventricular systolic function of patients with CHF
Abstract: Objective:To investigate the clinical effect of carvedilol on the plasma brain natriuretic peptide and left ventricular systolic function of the patients with chronic heart failure (CHF). Methods:87 cases were divided into 2 groups. In group A including 43 patients, diuretic, angiotensin converting enzyme inhibitor, vasodilator with or without digitalis were used, and group B including 44 patients were treated with carvedilol after preliminary remission in addition to the above routine treatment. After 6-month follow-ups were done, the partial cardiac function indexes, cardiac structure and plasma brain natriuretic peptide (BNP) concentration were evaluated according to the data before the treatment, after 1, 3 and 6 months of treatment. Results: After 1 month treatment, the BNP level was lower than that before treatment (P0.05), and the decrease was more apparently after 3 months of treatment, moreover, it showed a significant difference (P0.05) between the 2 groups. No statistical difference was detected between the data before and after 1 month treatment in the two groups cases in the index of left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic volume (LVEDV) and left ventricular ejection fraction (LVEF) (P0.05),while the data after 6 month treatment showed significant difference (P0.05). The plasma BNP concentration of 2 groups exhibited a positive correlation with LVEDD (r=0.51, P0.01) and a negative correlation with LVEF (r=-0.43, P0.01). Conclusion:Carvedilol has the effect of improving the cardiac function of patients with CHF. The change of BNP level is earlier than echocardiography index. So BNP level can be used as a reliable index for the treatment of chronic heart failure.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 1
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