Title: Biosynthesis of A40926,A Precursor of Semisynthesis Glycopeptide Antibiotic Dalbavancin
Abstract:It was reviewed that the recent advance on A40926,a precursor of a second-generation glycopeptides antibiotic,dalbavancin,developed after teicoplanin,including the structure,fermentation production,bi...It was reviewed that the recent advance on A40926,a precursor of a second-generation glycopeptides antibiotic,dalbavancin,developed after teicoplanin,including the structure,fermentation production,biosynthesis and structural modification of A40926.The biosynthesis gene clusters and synthetic route of A40926 were especially introduced.Dalbavancin,a novel semisynthetic derivative of A40926,showing more potent than vancomycin and teicoplanin,is now in the phase Ⅲ clinical trials.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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