Title: Molecular and cytogenetic studies on 10 patients with sexual abnomrmality.
Abstract: Objective:To analyze molecular and cytogenetic features of 10 patient with Sexual abnormality.Methods:Both chromosome Karyotypic and Y chromosome microdeletion analysed by Multiplex polymerase chain reaction for 9 sequence tagged sites(STS),including sY84,sY86,in AZFa,sY127,sY134,sY129 in AZFb,sY254,sY255 in AZFc,sY152 in AZFd,sY160(DYZ1)in Yq12 and SRY(sY14) were 10 patients with Sexual abnormality.Results:A 46,X,del(X)(q13) and a 45,X/46,X,+min female patients absencted SRY gene and Y-chromosome AZFa,b,c;a 46,XX and 46,X,-Y,+min males patients of the SRY gene and absence of Y-chromosome AZFa,b,c;two 46,XY and a 47,XYY female patients of the SRY gene and Y-chromosome AZFa,b,c;a 46,X,del Y(q11)female patients absence of Y-chromosome b,c;a 46,XY,Yqh-female patients absence sY160(DYZ1).Conclusion: Y-chromosome microdeletion analysis are important genetic assays Sex chromosome abnomality.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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