Title: Influence of Soybean Isoflavone on PKG and Raf-1 Expression in the Hippocampus of Rats with Alzheimer’s Disease
Abstract: Objective: To explore the effect and possible mechanism of action of soybean isoflavone(SIF) on PKG and Raf-1 expression in the hippocampus of rats with Alzheimer’s disease(AD).Method: Female Wistar rats were randomly divided into shame operation model control and SIF high,medium and low-dose groups.AD rat models were established by bilateral hippocampus injection of Aβ.Learning-memory abilities in AD rats were observed by Morris water maze test.PKG content in the hippocampus was measured by ELISA and Raf-1 expression in the hippocampus of rats was detected by immunohistochemistrical SP method.Result: SIF significantly improved learning-memory abilities(P0.05) and decreased PKG content and Raf-1 expression in the hippocampus of AD rats(P0.05).Conclusion: SIF has anti-AD effects probably by decreasing PKG content and Raf-1 expression in the hippocampus of AD rats.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 1
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