Title: SPARC and Her-2's expression in breast cancer tissue
Abstract: Objective To investigate SPARC and Her-2 in breast cancer tissue and its relationship with clinicopathological parameters. Methods Immunohistochemistry was used to detect the expression of 70 cases of breast cancer and 20 cases of breast fibroadenoma SPARC and Her-2's. Results SPARC overexpression in breast cancer rates between stromal cells 68.6%(48/70) was significantly higher than the rate of tumor cells expressing 37.1%(26/70)(P 0.05);mammary stromal cells SPARC expression rate of cancer in 68.6%(48/70) was significantly higher than the expression of breast fibroadenoma 40.0%(8/20)(P 0.05); in lymph node metastasis,TNM stage Ⅲ SPARC expression in breast cancer rates rise(P 0.05).Her-2 was mainly expressed on the membrane of breast cancer cells,high expression rate in breast cancer cells in 45.7%(32/70) was significantly higher than the expression of breast fibroadenoma 10.0%(2/20)(P 0.05). Her-2 expression rate of lymph node metastasis than those without lymph node metastasis high(P 0.05). Conclusion Breast Cancer SPARC,high expression of Her-2 breast cancer i ncidence,progression,metastasis and prognosis.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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Cited By Count: 1
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