Title: Effects of Transdermal Penetration Enhancers on the Permeation Properties of Dexamethasone Acetate Chitosan Gel
Abstract: Objective To study effects of penetration enhancers on the transdermal permeation of dexamethasone acetate chitosan gel. Methods The permeation enhancer-free group and enhancer added group were set up.There were 0.75% dexamethasone acetate and 5% chitosan gel in the permeation enhancer-free group.The permeation enhancer group was composed of 0.75% dexamethasone acetate and 5% chitosan gel,which subdivided into azone plus propylene glycol,azone,propylene glycol plus dimethyl sulfoxide,and dimethyl sulfoxide plus azone groups.Skin samples as permeability barriers were obtained from hairless rats for in vitro tests of the drug permeability.The permeation parameters,named as steady srate flux(Js)and Js enhancement ratio were evaluated. Results Js in the permeation enhancer-free group①was(3.75±0.56) μg·(cm2)-1·h-1,and that in the permeation enhancer group were(8.12±0.58) μg·(cm2)·h-1(dimethyl sulfoxide plus azone group②)(5.41±0.74) μg·(cm2)-1·h-1(Azone plus propylene glycol group③),(4.31±0.42) μg·(cm2)-1·h-1(propylene glycol plus dimethyl sulfoxide group④),(4.35±0.36) μg·(cm2)-1·h-1(azone group⑤,)respectively.Compared with ①,the Js enhancement ratio of ② was 2.17%(P0.01),and the Js enhancement ratio were 1.51,1.89,1.87(P0.05 or P0.01),respectively,compared with③,④,⑤,which all showed significant differences. Conclusion The mixed permeation enhancer has better permeation properties than the single enhancer.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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Cited By Count: 1
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