Title: Irradiation of the chest wall and regional nodes as an integrated volume with IMRT for breast cancer after mastectomy:from dosimetry to clinical observation
Abstract:Objective To discuss dosimetric characteristics of integrated volume for chest wall target and supraclavicular target with IMRT for breast cancer after mastectomy,and observe acute side-effects follow...Objective To discuss dosimetric characteristics of integrated volume for chest wall target and supraclavicular target with IMRT for breast cancer after mastectomy,and observe acute side-effects following irradiation.Methods It was plan for breast cancer after mastectomy of 146cases,the plan for integrated volume with IMRT for breast cancer in 43 cases choice3 fields for chest wall target area and 2 fields for supraclavicular target area and 1field for the total target area,the general plan in 103 cases was 3D-CRT for chest wall target joining plan of mixed irradiation by 6 MV X-ray and 9 MeV electronic line for supraclavicular target.prescription dose was 50 Gy/25 times,to meet the requirements of 90% prescription dose for target area;and dosimetry characteristics on the chest wall target and supraclavicular target area and normal organ are compared.Results The plan of integrated volume with IMRT for breast cancer for the chest wall target area compared with general plan reduces the maximum dose and enhance the minimum dose and a better target conformal and uniformity.The plan of integrated volume with IMRT for breast cancer for Supraclavicular target area compared with general plan,the minimum dose and the average dose of prescription dose and 95% contains the target volume,and conformal and uniformity for the target region was increased obviously.The plan of integrated volume with IMRT for breast cancer for the normal organ compared with general plan,the V30 and V10 and V30 and Dmean of the ipsilateral lung and heart were lowed,while the V5 and V10 of the ipsilateral lung and heart were increased,it were no statistical difference of V20 of the ipsilateral lung and Dmean of the contralateral lung and Dmean of the contralateral breast,≥grade 2 radiational dermatitis was identified in 38% patients,no patient developed radiation pneumonitis.Conclusion The plan for integrated volume with IMRT for breast cancer can improve the dose of supraclavicular target significantly by the quantity under the premise for organ at risk and improve conformal and uniformity of the dose for chest wall target area and supraclavicular target volume.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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