Title: Oxcarbazepine and carbamazepine in the treatment of primary trigeminal neuralgia:systemic review and Meta-analysis
Abstract: Objective To compare the efficacy and safety of oxcarbazepine and carbamazepine for primary trigeminal neuralgia management.Methods Cochrane library,Pub Med,Medline,CBMdisc,CNKI and Wanfang Data were searched to collect the randomized controlled studies that compared the efficacy and safety of oxcarbazepine and carbamazepine in treating primary trigeminal neuralgia. Reference list of each primary study was hand- searched. Two reviewers independently screened the literatures,extracted data,assessed risks of bias and then did cross-checking. Rev Man 5. 2 software was used for Meta- analysis. Results Eighteen studies( 1465 participants) were included. Results of Meta-analysis showed that oxcarbazepine was more effective than carbamazepine [RR = 1. 09,95% CI( 1. 02,1. 16),P 0. 05]. Comparisons of VAS before and after 2 and 4 weeks of treatment were not significantly different between two groups,while comparisons of VAS before and after the 8weeks of treatment favored oxcarbazepine. Oxcarbazepine was associated with a lower incidence of adverse drug reaction than carbamazepine[RR = 0. 50,95% CI( 0. 39,0. 63),P 0. 001]. The influence of reporting bias is small. Conclusion Compared with carbamazepine,oxcarbazepine is not inferior in efficacy but superior in safety in treating primary trigeminal neuralgia.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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