Title: Clinical study of Irbesartan on improving arterial elasticity and pulse pressure in essential hypertensives
Abstract:Objectives To investigate the effects of Irbesartan on arterial elasticity,wave reflection and pulse pressure in essential hypertensives with pulse pressure of 60 mm Hg(1 mm Hg=0.133 kPa)or more.Metho...Objectives To investigate the effects of Irbesartan on arterial elasticity,wave reflection and pulse pressure in essential hypertensives with pulse pressure of 60 mm Hg(1 mm Hg=0.133 kPa)or more.Methods Thirty elderly essential hypertensives with pulse pressure of 60 mm Hg or more [13 males and 17 females,average age (65.2±8.5)years]were enrolled and divided into two groups in equal number(treatment and controlled groups).The treatment group received Irbesartan (150 mg/d)individually and the controlled group with placebo therapy for 12 weeks.Brachial blood pressure was measured by standardized mercury cuff sphygnomanometer.Au- tomatic pulse wave velocity(PWV)measurement system and DO-2020 Arterial Pulse Contour Instrument were ap- plied to examine the carotid-femoral PWV (CF-PWV)and the large and small arterial elastic indexes(C_1 and C_2) respectively.Central arterial pressure,augmentation pressure and augmentation index(AI)were acquired by using the radial pulse wave analysis system.Results After three months treatment,the controlled group showed insig- nificant changes of pulse pressure and artery elasticity index.The treatment group,after excluding the placebo effect,showed significant increase of C_1 and C_2,CF-PWV slowed down obviously;both augmentation pressure and AI dropped significantly;together with significant decrease of peripheral and central systolic pressure,diastolic pressure and pulse pressure.The decreased blood pressure could partialy explain the improvement of large artery elasticity.Conclusion Irbesartan improves the small and large arterial elasticity,attenuates the wave reflex ampli- tude and reduces pulse pressure in the essential hypertensives with pulse pressure of 60 mmHg or more.(Shanghai Med J,2006,29:636-639)Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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