Title: Effect of aminiguanidine on inducible iNOS and cell apoptosis during acute cardiac allograft rejection in rats
Abstract: Aim: To investigate the effects of a selective iNOS-blocking drug (aminiguanidine,AG) on the cell apoptosis during acute cardiac allograft rejection in rats. Methods: Rat heterotopic cardiac transplantation model was used. Group A: heart transplantation group with Wistar rat donor and Wistar rat recipient was given physiological saline(1 ml) subcutaneously once per day; Group B: heart transplantation group with SD rat donor and Wistar rat recipient was given physiological saline(1 ml) subcutaneously once per day; Group C: heart transplantation group with SD rat donor and Wistar rat recipient was treated with AG subcutaneously once per day. In each group the transplanted hearts were harvested on the 3rd, 5th, and 7th day, respectively. The cardiac allograft rejection, the cell apoptosis and iNOS activity were detected. Results: The pathological grades of cardiac allograft rejection in group B and C had significant difference (P0.05). The apoptotic index increased with the severity of the cardiac allograft rejection.Compared with Group B, iNOS activities in Group C obviously increased at all the time stage. Conclusion: Apoptosis during acute rejection can be relieved by preconditioning with AG, and the function of the transplanted hearts can be protected.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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