Title: Conformal radiotherapy for elderly patients with non-small-cell lung carcinoma
Abstract: Objective:To evaluate the effect and value of three-dimensional conformal radiotherapy(3DCRT) on non-small-cell lung carcinoma(NSCLS)in the elderly.Methods:One hundred and thirty-two cases with NSCLS were randomly divided into conventional radiotherapy plus 3DCRT group and conventional radiotherapy(CT)group.The first stage,both of the two groups were initially treated by the same conventional radiotherapy at a dose of 40 GY,20 fractions for four weeks.The second stage,the patients in 3DCRT group were then administered 3DCRT in 2-3 GY/f,5fractions a week at a dose of 20-28 GY.The patients in CT group received the same CT at a dose of 20 GY,10 fractions for two weeks.Results:The total effective rates were 95.5% in 3DCRT group and 84.9% in CT group.The 2,3-year survival rates were 48.5%,33.3% in 3DCRT group and 30.3%,16.7% in CT group.The difference of the two groups was significant statistically(P﹤0.05).The incidences of radiation pneumonitis,Ⅰ,Ⅱradiation esophagitis and radiation pulmonary fibrosis were milder in the 3DCRT group than that in the CT group.There was significant difference statistically between the two groups(P﹤0.01).Conclusion:In treatment of NSCLC in the elderly,conventional radiotherapy followed by 3DCRT may increase the 2,3-year survival rate,quality of life and decrease the radiation reaction.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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