Title: Clinical observation of colon cancer radical surgery by laparoscopic with dexmedetomidine and remifentanil in elderly hypertensive patients
Abstract: Objective To observe the effects of anesthesia with dexmedetomidine and remifentanil in elderly hypertensive patients undergoing laparoscopic colon resection hemodynamic. Methods 60 cases of laparoscopic colon cancer in elderly hypertensive patients intended to impose radical surgery w ere randomly divided into dexmedetomidine group 1( group D1),dexmedetomidine group 2( group D2),and the control group( group C),20 cases in each group.At 10 min before induction of anesthesia,group D w as given dexmedetomidine infusion,0. 8 μg / kg,and then group D1,D2respectively w as given 0. 4 μg /( kg·h) and 0. 2 μg /( kg·h) continuous infusion. And the group C w as given normal saline at the same time. Conventional induction,sevoflurane,remifentanil and rocuronium w ere used to maintain anesthesia. The mean arterial pressure and heart rate w ere recorded at the time that into the chamber( T0),after administration 5 min( T1),intubated immediately( T2),after intubation 1 min( T3),after intubation 5 min( T4),surgical skin incision( T5),the beginning of surgery 30 min( T6),immediate extubation( T7) and after extubation 5 min( T8). When intraoperative blood pressure 180/100 mmHg,urapidil hydrochloride injection was given,25 mg,when heart rate 110 bpm,esmolol hydrochloride injection w as given,20 mg. The restlessness score,sedation score and recovery time w ere observed. Results The mean room entrance arterial pressure and heart rate of the three groups had no significant difference( P 0. 05); the mean arterial pressure and heart rate of group D1and D2after administration5 min,intubated immediately after intubation 1 min,after intubation 5 min,surgical incision,the surgery begins 30 min,5 min after extubation extubation immediate,w ere significantly low er than those of group C( P 0. 05); the mean arterial pressure and heart rate of group C at 5 minutes after extubation remained significantly higher than that of group D( P 0. 05); agitation score of group C was significantly higher than that of group D1and group D2( P 0. 05); sedation scores of group C w ere significantly low er than those of group D1and group D2( P 0. 05); the recovery time of group D1w as significantly higher than that of group D2and group C. Conclusion Dexmedetomidine and remifentanil can reduce colon cancer in elderly hypertensive patients undergoing laparoscopic induction period and the emergence of non-reactive,more stable hemodynamics,0. 2 μg /( kg·h) continuous infusion of remifentanil is the ideal choice.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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