Title: Relationship of polymorphism in angiotensin-converting enzyme gene with left ventricular hypertrophy and essential hypertension
Abstract:Objective To investigate the relationship of polymorphism of angiotension converting enzyme (ACE) gene with essential hypertension (EH) and left ventricular hypertrophy (LVH) in hypertensive patients....Objective To investigate the relationship of polymorphism of angiotension converting enzyme (ACE) gene with essential hypertension (EH) and left ventricular hypertrophy (LVH) in hypertensive patients. Methods Clinical data were collected in 136 patients with EH and 110 controls. Left ventricular mass and geometry were assessed with ECG and duplex sonography in hypertention patients. DNA was extracted from peripheral blood leukocytes. The insertion/deletion polymorphism of ACE gene was monitored by polymerase chain reaction (PCR). Results The analysis of individual ACE genotypes and allele frequencies distribution showed no significant difference between EH and controls. ACE gene showed a significant difference in genotype or allele frequencies distribution between LVH + groups and LVH - groups (P0.05). Conclusions No association between the polymorphism of ACE gene and EH is found. A significant association between the polymorphisms of ACE gene in EH is detected, and allele I of ACE gene may be an independently risk factor for LVH in hypertention patients. There is a synergistic effect between the polymorphism of ACE gene and LVH in EH.Read More
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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