Title: Expression and significance of HIF-1α and CXCR4 protein in tissues of breast cancer
Abstract: Objective To investigate the expression of hypoxia-inducible factor-1α(HIF-1α) and chemokine receptor 4(CXCR4) protein in tissues of breast cancer and its association with clinicopathological features.MethodsThe expression of HIF-1α and CXCR4 protein in 60 breast cancer,30 breast fibroadenoma and 20 normal breast samples were detected by immunohistochemistry,and the relationship between the expression of HIF-1α and CXCR4 protein in the tissues of breast cancer and its association with clinicopathological factors were analysed.ResultsThere was no positive expression of HIF-1α and CXCR4 protein in normal breast tissues.The positive expression rates of HIF-1α protein in tissues of breast cancer and breast fibroadenoma were 65.0% and 26.7%,respectively(P0.05),and that of CXCR4 protein were 56.7% and 23.3%,respectively(P0.01).The expression of HIF-1α protein was closely related to lymph node metastasis,tumor stage,histological grade and expression of vascular endothelial growth factor(VEGF)(P0.05),but not related to age,tumor size and expression of estrogen receptor(ER) and progesterone receptor(PR).The expression of CXCR4 protein was closely related to lymph node metastasis,tumor stage and expression of VEGF,ER and PR(P0.05),but not related to age,tumor size and histological grade.The expression of HIF-1α protein was positively related to that of CXCR4 protein(r=0.346,P=0.007).ConclusionThe high expression of HIF-1α and CXCR4 protein in tissues of breast cancer is closely related to the carcinogenesis,development and lymph node metastasis.The joint detection of the expression of HIF-1α and CXCR4 protein has benefit in evaluation of the biological behaviour of breast cancer,increases the accuracy in prognosis prediction and plays an important role in the clinical treatment guidance.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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