Title: THE CLINICAL STUDY OF ACCELERATED HYPERFRACTIONATION FOR ESOPHAGEAL CARCINOMA DURING INTERMEDIATE-LATE COURSE RADIOTHERAPY
Abstract: Objective:To evaluate the effect of the accelerated hyperfractionation boost at the last three weeks of the radiotherapy course for esophageal carcinoma.Methods:59 patients with esophageal carcinoma were randomized into two groups:the conventional fractionation(CF) group (29 patients)and late course accelerated hyperfractionation (LCAH) group (30 patients).All were squamous cell carcinoma.Patients in CF received 2Gy per fraction,5 fractions a week to total dose of 72Gy in 7.2 weeks.Patients in LCAH received the 30Gy/3wk at fist,then followed by accelerated hyperfractionation with 1.4Gy per fraction,two fractions per day with 6 hours interval to a total dose of 41.2Gy in 3.8 weeks,then shrinked the fields to a total dose of 72 Gy in 6 weeks.Results:The one-year survival rates and local tumor control rates in LCAH group were significantly improved when compared to the CF group,being respectively 70% vs 39.1%,and 73.9% vs 42.3% .The improvement of swallowing obstruction symptoms in LCAH group was much better than that in CF group (P0 01).There was no significant difference between two groups about clinical radiotherapy symptoms and biopsy irradiated.Conclusion:The preliminary results from our study in a small group of patients has shown that the one-year survival rates and local tumor control rates of patients with esophageal carcinoma can be improved by LCAH without increasing any complication.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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