Title: Ontogeny of gastrin cells in mouse gastrointestinal tract
Abstract: Objective: To study the ontogeny, distribution, morphology and the quantitative changes of gastrin cells (G cells) in mouse gastrointestinal tract, providing information for further disclosing the G cell function and its related research.Methods: Immunohistochemical method was used. Results: G cells could be found in the mouse gastric antrum at ED 17, and in the small intestine at ED 18. The number of G cells of the mouse gastrointestinal tract was the greatest in the duodenum during embryonic period and in the gastric antrum after birth. The processes of G cells could be seen extending to the free surface of the epithelium, between the adjacent cells, or to the basement membrane and around capillaries. The immuno positive substance were detected in the lumen of the gastrointestinal tract and in area around the G cells. Conclusion: The ontogeny and the quantitative change of G cells in the mouse gastrointestinal tract have their species specificity. G cells may possess endocrine, paracrine and exocrine functions simultaneously.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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