Title: Homocysteine alters monocyte-endothelial interaction in vitro.
Abstract: To determine whether homocysteine induced endothelial damage through monocyte-endothelial interaction and to characterize both cell types in vitro.Radiomethods were performed on monocyte adhesion to/through endothelium and endothelial damage experiments.Homocysteine-treated endothelial cells increased monocyte adhesion and transmigration. Homocysteine-treated monocytes induced endothelial detachment, but this effect was blocked by catalase. These effects were increased with higher concentrations of homocysteine. Monocyte surface glycoprotein antibodies CD11b/CD18 and CD14 inhibited these processes.Homocysteine alters monocyte-endothelial interaction in vitro, eventually bringing about endothelial damage through release of H(2)O(2). These phenomena are mediated through monocyte surface glycoproteins CD11b/CD18 and CD14. Upregulation of these processes in vivo may contribute to acceleration of atherosclerosis in patients with elevated plasma homocysteine levels.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 6
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