Title: The Inhibiting Effect of Hesperidin on Proliferation of Esophageal Cancer Eca9706 Cells
Abstract:The inhibiting effect of hesperidin on proliferation of esophageal carcinoma cells and its influence on cell apoptosis and cell cycle were observed by MTT assay and FCM.The results showed hesperidin w...The inhibiting effect of hesperidin on proliferation of esophageal carcinoma cells and its influence on cell apoptosis and cell cycle were observed by MTT assay and FCM.The results showed hesperidin with various concentrations effectively inhibited the proliferation of Eca9706 cells in dose dependent,compared with the control group(P 0.01),IC50 was 84μg/mL.The proportions of the cell cycle in S phase were respectively 25.16%,30.13%and 31.05%,the cells apoptosis rates were respectively 6.23%,8.19% and 10.62% in hesperidin concentrations of 22μg/mL,43μg/mL and 84μg/mL after 48 h.There is a significant increase compared with the control group(P 0.002).The results indicated that hesperidin could significantly inhibit the proliferation of Eca9706 cells through interfering cell cycle and apoptosis.Read More
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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