Title: The expressions of angiostatin and correlation with VEGF in carcinoma of prostate
Abstract: Objective:To observe the relationship between VEGF and angiostatin in patients with carcinoma of prostate and benign hyperplasia of prostate.Methods:30 carcinoma of prostate tissue and 30 benign hyperplasia of prostate tissue were tested by using immunohistochemicaI and Western blotting technology.Results:The positive staining average grey value of angiostatin in carcinoma of prostate was increased significantly compared with that of benign hyperplasia of prostate,but the positive staining average grey value of VEGF in carcinoma of prostate was decreased compared with that of benign hyperplasia of prostate.The negative correlation was found between A S and VEGF (r=-0.560 P0.05;).Conclusion:The level of angiostatin expression is reduced in carcinoma of prostate;however,the level of VEGF expression is increased significantly in carcinoma of prostate,and the negative correlation was found between AS and VEGF in carcinoma of prostate).AS and VEGF may effect development and growth mechanism of carcinoma of prostate in biology.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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