Title: The role of coexpression of COX-2 and VEGF-C in lymph node metastasis in patients with colorectal carcinoma
Abstract: Objective To explore the coexpression of cyclooxygenase-2(COX-2) and vascular endothelial growth factor-C(VEGF-C) in colorectal carcinoma and their correlation with lymph node metastasis and prognosis.Method The expressions of COX-2 and VEGF-C were detected in 54 cases of colorectal carcinoma by immunohistochemical stain(S-P method).Results The positive rate of COX-2 was 72.2% and that of VEGF-C was 64.8%.There were significantly differences between the patients with lymph node metastasis and those without node involvement(P 0.05 for both comparisons).Both COX-2 and VEGF-C expression were related to the depth of invasion and Duke's stage(P 0.05 for both comparisons) but not to degree of differentiation(P 0.05).COX-2 expression was significantly related to VEGF-C expression(P 0.01).Conclusions The coexpression of COX-2 and VEGF-C may enhance the ability of colorectal carcinoma to invade locally or to metastasize.Detection of both COX-2 and VEGF-C expressions is beneficial in estimating the degree of the malignancy and predicting the prognosis.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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