Title: Guillain-Barré syndrome and Campylobacter jejuni infection
Abstract:Guillain-Barre syndrome (GBS) is viewed as a self-limited, autoimmune disease triggered by a preceding bacterial or viral infection,and Campylobacter jejuni(CJ) is the most frequent antecedent pathoge...Guillain-Barre syndrome (GBS) is viewed as a self-limited, autoimmune disease triggered by a preceding bacterial or viral infection,and Campylobacter jejuni(CJ) is the most frequent antecedent pathogen.Studies on the core oligosaccharide (OS) of C. jejuni lipopolysaccharide (LPS) from serotypes including O:1, O:2, O:4, O:10, O:19, O:23, O:36 and O:41 have revealed structures that mimic human gangliosides,the antiganglioside autoantibody from cross-react against lipopolysaccharide and ganglioside of peripheral nerves is the possible pathogenesis of GBS.The specificity of various antiganglioside antibody profiles in GBS can be used in diagnosis and prognosis of acute peripheral neuropathies.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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